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A specialized peptide built backwards (D-amino-acid retro-inverso) to disrupt a specific cell-aging signal in research models.
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FOX04-DRI is a clever piece of peptide engineering. It's modeled on a section of the FOXO4 transcription factor that normally talks to p53 inside aging ("senescent") cells. By building it with mirror-image amino acids in reverse order, researchers create a molecule that's much more stable in lab conditions than a natural peptide.
How it's been studied: Published work — notably from the Demaria lab — used FOX04-DRI as a research tool to break the FOXO4-p53 connection inside senescent cells, which then triggers them to clear out (a "senolytic" mechanism). All work has been in cultured cells and aged mice.
Where you'll see it in research:
Handling notes: The mirror-image build resists most everyday lab proteases. Standard cold-storage handling.
Every batch is third-party tested for purity, identity, and contaminants. Download the COA for the lot you receive.
Molecular Weight
≈ 2257 g/mol
Form
Lyophilized powder
Storage
Lyophilized: 2-8°C up to 24 months. Reconstituted: 2-8°C, use within 30 days.
Sequence
ltlrkrrwklllrwl (D-retro-inverso)
All compounds are sold individually and do not include reconstitution supplies, syringes, or aliquoting tools. Products ship in lyophilized (freeze-dried) form and require proper reconstitution before use in research settings. See our Reconstitution Solution page for laboratory-grade bacteriostatic water.
Research use only — not for human or animal consumption. See our Research Use Disclaimer.
