A 16-amino-acid peptide encoded inside mitochondrial DNA — studied in metabolism and aging research.
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MOTS-c is unusual — it's encoded inside mitochondrial DNA, not the nucleus. Scientists discovered it relatively recently, hidden inside a stretch of mitochondrial RNA. It's part of a small family of "mitochondrial-derived peptides," and research has built up around it as a tool for studying metabolism and how mitochondria talk to the rest of the cell.
How it's been studied: Research from the Cohen and Lee labs has examined how MOTS-c switches on AMPK (a master metabolic enzyme), how it influences glucose uptake in muscle-cell lines, and how it acts as a signal from mitochondria back to the cell nucleus.
Where you'll see it in research:
Handling notes: Standard peptide handling. The peptide is amphipathic (it has both water-loving and oil-loving regions) so make sure it fully dissolves on reconstitution.
Every batch is third-party tested for purity, identity, and contaminants. Download the COA for the lot you receive.
Molecular Weight
2174.59 g/mol
Form
Lyophilized powder
Storage
Lyophilized: 2-8°C up to 24 months. Reconstituted: 2-8°C, use within 30 days.
Sequence
MRWQEMGYIFYPRKLR
All compounds are sold individually and do not include reconstitution supplies, syringes, or aliquoting tools. Products ship in lyophilized (freeze-dried) form and require proper reconstitution before use in research settings. See our Reconstitution Solution page for laboratory-grade bacteriostatic water.
Research use only — not for human or animal consumption. See our Research Use Disclaimer.
