Research Library
Explore our collection of research articles, guides, and protocol documentation.
Research & Science
TB-500 is a synthetic N-acetylated heptapeptide with the sequence Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (Ac-LKKTETQ), corresponding to residues 17-23 of the parent protein thymosin β4. The fragment is the actin-binding stretch of the parent and is widely used in cell-culture work as a discrete reagent. This research-use-only reference covers its primary chemistry, the relationship to thymosin β4, the actin-sequestering mechanism, the structural rationale for the N-terminal acetylation, the in-vitro endpoints commonly reported across the literature, the in-vitro metabolism profile, and the current regulatory framing.
Research & Science
Tirzepatide (LY3298176, marketed as Mounjaro and Zepbound) is a synthetic 39-amino-acid peptide engineered from a glucose-dependent insulinotropic polypeptide backbone. It is a dual agonist at the GIP and GLP-1 receptors. This research-use-only reference covers its primary structure, the two engineered Aib residues that give it protease resistance and tuned receptor activity, the cryo-EM evidence for how a single continuous α-helix engages both Class B GPCRs in distinct conformations, the imbalanced potency profile and biased agonism at GLP-1R, and the regulatory framing for laboratories ordering research-grade material.
